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Named after Jean Baptiste Girardot, who established a trading post here in 1733, Cape Girardeau, on the banks of the Mississippi River, was settled by Spanish immigrants drawn to the area by Spain's offer of inexpensive, tax-exempt land. Flourishing river trade characterized the town before the Civil War. Cape Girardeau experienced an industrial resurgence in the 1880s with the establishment of new railroad lines. Learn More...